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This part of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the people that go through it one should err on the side of caution and allow FDA do its job and demand some investigation be done so that the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate income and that they would say almost anything to keep people on their own medications. Researchers found that participants using this drug for a year, lost excess weight within four weeks and have kept the body weight off throughout the 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which can be made up of many active ingredient, which can make them more efficient and safer. Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that as of right now there are no long term prescription weightloss pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure and heartbeat, and shouldn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure and heartbeat and must stop used in patients with uncontrolled high blood pressure, along with by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients for the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. --Participating in support groups which help the family from the addict recover (for example Al-Anon or Nar-Anon).